2008-2009 Session
October 8th 2008, 2pm to 5pm at MANDEC (Manchester Dental Education Centre), Higher Cambridge Street (tea will be served about mid-afternoon) (building 41, entrance on corner facing building 35) Joint meeting with Manchester University's Biostats Group Theme: Analysis challenges arising from post-genomic high-dimensional datasets XIAYI KE (Centre for Integrated Genomic Medical Research, School of Medicine, University of Manchester)Genome-wide association studies of rheumatoid arthritis Genome wide association studies have been very successful in identification of disease susceptibility loci for various complex human diseases in recent 2-3 years. The Wellcome Trust Case Control Consortium (WTCCC) is the best example of this development, where seven common complex diseases, including rheumatoid arthritis (RA), have been investigated and a number of disease susceptibility loci have been uncovered. Before genome-wide association was applied to RA, there were only two genetic loci known to be associated with RA. Now more than ten novel loci have been identified. Despite these successes, all these genetic factors identified so far can only explain about 10% of the disease susceptibility variance, leaving wide open where is the rest of genetic contribution and how to find each element. In this talk, RA will also be used as an example to illustrate the classical relationships between sample size, power, effect size, and type I errors. Challenges in localization of causal variants and detection of gene-gene interactions will also be discussed. DAVID HOYLE (Health Methodology Research Group, School of Community Based Medicine, University of Manchester)Properties of sample covariance matrices from modern high-dimensional genomic data sets Modern biotechnology is providing a wealth of new data sets that are high-dimensional but comparatively low sample size. This presents challenges for traditional methods of analysis. Understanding the properties of sample covariance matrices under such conditions has become a recent research focus. In this talk I will outline new findings and my own research in this area. Neil Lawrence (School of Computer Science, University of Manchester)
Meeting contact: Stephan Rudolfer 10th December, 5pm, Room G.107, Alan Turing Building, University of Manchester. Meeting contact: Stephan Rudolfer 15th January, 2009 All Day on Statistics in the City Meeting contact: Margaret Martin February 11th, 5pm, Room G.107, Alan Turing Building, University of Manchester. Meeting contact: Stephan Rudolfer March 11th, 5pm, Room G.107, Alan Turing Building, University of Manchester. Meeting contact: Stephan Rudolfer 29th April, 5pm, Room G.107, Alan Turing Building, University of Manchester. Meeting contact: John Logsdon July 8th 2009, 4.30pm, Room G.107, Alan Turing Building, University of Manchester
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